Ketamine works by blocking the action of a neurotransmitter called glutamate, which is involved in many brain functions, including mood regulation. By blocking glutamate, ketamine can help increase the levels of another neurotransmitter, called serotonin, which is often low in people with depression and anxiety.
Ketamine works by blocking the action of the N-methyl-D-aspartate (NMDA) receptor, which is a type of glutamate receptor in the brain. By blocking this receptor, ketamine can produce a dissociative state and provide analgesia and anesthesia.
However, the exact mechanism of how ketamine works in treating mental health conditions such as depression, anxiety, and post-traumatic stress disorder (PTSD) is not fully understood.
It is believed that ketamine’s effects on other neurotransmitter systems, such as the glutamate and GABA systems, may play a role in its antidepressant and anxiolytic effects.